pentobarbital will lower the level or influence of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Pitolisant publicity is decreased by fifty% if coadministered with strong CYP3A4 inducers.pentobarbital will lessen the level or influence of ixabepilone by impacting hepatic/intestinal enzyme CYP3A